Chrome: there was a fairly annoying bug which was messing with reordering of panels. Try again now, though, I just pushed out changes that should make that work much better -- if all your panels have disappeared, you might need to reset them to their original settings

IE: Hmmmmm. That's not the first I've heard of IE, in particular, not liking the JS. Can you look into the error log / error console and tell me if it's choking on anything? (security setting: it should just be normal JS, if the other JS on DW works for you, that's likely not it)